the sky looks like some teenage hipster’s blog theme tonight
Although babies are born into a world replete with diverse bacteria, the ones that colonize them are not accidental. These first microbes colonizing the newborn begin a dynamic process. We are born with innate immunity, a collection of proteins, cells, detergents, and junctions that guard our surfaces based on recognition of structures that are widely shared among classes of microbes. In contrast, we must develop adaptive immunity that will clearly distinguish self from non-self. Our early-life microbes are the first teachers in this process, instructing the developing immune system about what is dangerous and what is not.
In our first three years of life, a great diversity of microbes self-organizes into a life-support system with the complexity of the adult microbiota. This critical period lays the foundation for all the biological processes that unfold in our childhood, adolescence, adulthood, and old age—unless something comes along to disrupt it.
Lactobacillus organisms and vaginal squamous epithelial cell. Image: CDC via Wikipedia
a moment of silence for the last 4/13 we’ll ever have
A happy 4/13 to all of you. ♥ NYstuckers, I know the younger crew are hanging out at Washington Square Park today to celebrate this most important of holidays, so if you do not loathe the daystar, this may be a thing you want to go attend. :)
alveolar macrophage and Mycobacterium tuberculosis
IT’S A TRAP
mycobacterium hide from the immune system…within the immune system…by taking residence inside macrophages in the lung